Topical Generalization for Presentation of User Profiles

Fine-grained user profile generation approaches have made it increasingly feasible to display on a profile page in which topics a user has expertise or interest. Earlier work on topical user profiling has been directed at enhancing search and personalization functionality, but making such profiles useful for human consumption presents new challenges. With this work, we have taken a first step toward a semantic layout mode for topical user profiles. We have developed a topical generalization approach which finds coherent groups of topics and adds labels to them, based on their association with broader topics in the Wikipedia category graph. A nested layout mode, employing topical generalization, is compared with a simpler flat layout mode in our user study. The results indicate that users favor the nested structure over flat profiles, but tend to overlook the specific topics on the lower level. We propose a third layout mode to address this issue.Comment: (to be) presented at DIR'16, November 25, 2016, Delft, The Netherland

Long-Term Locoregional Vascular Morbidity After Isolated Limb Perfusion and External-Beam Radiotherapy for Soft Tissue Sarcoma of the Extremity

Background: Isolated limb perfusion (ILP) with tumor necrosis factor alpha (TNF-alpha) and melphalan, followed by delayed surgical resection and adjuvant external-beam radiotherapy is a limb salvage treatment strategy for locally advanced soft tissue sarcomas. The long-term vascular side effects of this combined procedure were evaluated. Methods: Thirty-two patients were treated for a locally advanced sarcoma of the upper (n = 5) or lower limb (n = 27). All patients underwent a noninvasive vascular work-up. Results: Five patients underwent a leg amputation, in two cases due to critical leg ischemia 10 years after ILP. With a median follow-up of 88 (range, 17-159) months, none of the patients with a salvaged lower leg (n = 22) experienced peripheral arterial occlusive disease. Ankle-brachial index (ABI) measurements in the involved leg (median, 1.02; range, .50-1.20) showed a significant decrease compared with the contralateral leg (median, 1.09; range, .91-1.36, P = .001). Pulsatility index (PI) was decreased in the treated leg in 17 of 22 patients at the femoral level (median, 6.30; range, 2.1-23.9 vs. median, 7.35; range, 4.8-21.9; P = .011) and in 19 of 20 patients at popliteal level (median, 8.35; range, 0-21.4 vs. median, 10.95; range, 8.0-32.6; P <.0005). In patients with follow-up of > 5 years, there was more often a decrease in ABI (P = .024) and PI at femoral level (P = .011). Conclusions: ILP followed by resection and external-beam radiotherapy can lead to major late vascular morbidity that requires amputation. Objective measurements show a time-related decrease of ABI and femoral PI in the treated extremity